As questioned in a lot of places (
here (Nick Bradbury),
here) the recent anouncment on the aquisition of Macromedia by Adobe makes the future of Homesite very uncertain.
I used Homesite when I started with Webdev (1999), and at that time it seemed like a good tool. Especially features like it's multi-line search-and-replace where among my favorites. I always preferred Homesite to Dreamweaver and it's competitors.
Unfortunatly I found Homesite totally lacking in terms of CSS support and that's why I got to love Topstyle Pro once I'd found it

(Dreamweaver was, until recently, no option for CSS as well). That led to me completely abandoning Homesite, which wasn't really developed any more anyway.
As history has shown (Macromedia itself cancelled projects like "Kawa" when the aquired Allaire, I think Homesite will vanish.
Lately I have been using
PHPEclipse a lot.
Eclipse and it's
Web Tools Project have a lot of advantages over any other text-based platform: Especially the plugins which add SQL support and SCM are something you cannot expect from a smaller project like Topstyle Pro (Which is something any larger project needs).
I'd love to see a Topstyle Pro port to Eclipse, as e.g. the UI matches Eclipse's "Views" and "Perspectives". As Nick is a Delphi developer that won't happen, but maybe someone else is up to the task. Until now there is no decent CSS / HTML editor for the Eclipse platform (commercial or non-commercial).
That said, I think Macromedia left Homesite to die long ago, and I don't think Adobe will change that.